NIH StrokeNet National Coordinating Center for year 2023 (U01 Clinical Trials Not Allowed) | RFA NS 23 009

Opportunity Information: Apply for RFA NS 23 009

The NIH StrokeNet National Coordinating Center (NCC) funding opportunity for 2023 (RFA-NS-23-009) is a National Institutes of Health cooperative agreement (U01) issued by the National Institute of Neurological Disorders and Stroke (NINDS). It supports the central hub responsible for overall coordination of the NIH Stroke Trials Network, a national infrastructure originally established in 2013 to make multi-site stroke research faster, more consistent, and higher quality. The network is designed to advance promising interventions across the full continuum of stroke care, with an intentional balance across three major areas: stroke prevention, acute treatment, and recovery/rehabilitation.

At its core, the FOA is about running and strengthening a standardized national system that can efficiently develop, launch, and execute complex, multi-site studies. The NIH StrokeNet portfolio includes multi-site exploratory studies and confirmatory Phase 3 clinical trials, along with biomarker-validation studies that are immediately preparatory to trials. The announcement also highlights ancillary studies that add scientific aims to trials already underway. While the network exists to support clinical trials activity broadly, this specific U01 is labeled "Clinical Trials Not Allowed," meaning the NCC award itself is intended to fund coordination and network operations rather than to directly conduct an applicant-led clinical trial as the primary purpose of this award.

The NCC role is to provide leadership and day-to-day operational coordination across the network, working closely with two other major network components that are funded under separate announcements: the National Data Management Center (NDMC) and multiple Regional Coordinating Stroke Centers (RCCs). Together, these components create an end-to-end platform for protocol development and implementation, trial startup, and consistent conduct across sites. The FOA emphasizes strong collaborative relationships spanning the many disciplines involved in stroke care and research, including vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology. A major practical objective of the NCC is to help the RCCs leverage their clinical and scientific expertise to recruit stroke patients into multiple ongoing studies and trials across the network.

In terms of eligibility, the opportunity is broadly open to many U.S.-based organization types. Eligible applicants include state, county, and local governments; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; special district governments; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses) as well as small businesses; and other organizations as allowed by NIH policy. The FOA explicitly notes additional categories often highlighted for NIH opportunities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and eligible federal agencies.

Restrictions on foreign involvement are clear and strict. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply. Non-domestic components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed. In practice, that means the coordinating center and its supported activities must be entirely domestic in terms of applicant organization and allowed components.

Administratively, this is a discretionary funding opportunity using a cooperative agreement mechanism, which generally implies substantial NIH program involvement compared with a standard research grant. The assistance listing (CFDA) number is 93.853. The posted award ceiling is $1,750,000, and the original application due date was February 28, 2023 (with a creation/posting date of December 15, 2022). Overall, the funding is aimed at sustaining the national coordination backbone required to run a large, multi-center stroke research enterprise, ensuring consistent processes, efficient study launch and management, and a durable infrastructure that can support high-priority stroke prevention, treatment, and recovery research across the United States.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH StrokeNet National Coordinating Center for year 2023 (U01 Clinical Trials Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853.
• This funding opportunity was created on 2022-12-15.
• Applicants must submit their applications by 2023-02-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $1,750,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA NS 23 009

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