NIBIB Research Project Grant (R01 Clinical Trial Required) | PA 18 418

Opportunity Information: Apply for PA 18 418

The NIBIB Research Project Grant (R01 Clinical Trial Required), funding opportunity number PA 18 418, is a National Institutes of Health (NIH) discretionary grant designed to support a clearly defined, investigator-led research project. The R01 mechanism is meant for a discrete and well-scoped plan of work with specific aims, methods, and outcomes that fit the expertise of the research team. What makes this particular announcement distinct is that it requires applicants to propose at least one clinical trial as part of the project. In practical terms, the research cannot be purely preclinical or theoretical; it must include a trial involving human participants that meets NIH definitions for a clinical trial, and it must be directly connected to the scientific goals of the application.

The proposed work must align with the programmatic interests of the National Institute of Biomedical Imaging and Bioengineering (NIBIB). While the listing does not spell out particular scientific topics, NIBIB generally supports research at the intersection of engineering, imaging, and biomedical technology development and evaluation. Applicants should expect that the project will be assessed not only for scientific merit and feasibility, but also for how clearly it advances NIBIB-relevant areas and how appropriately the clinical trial is designed, justified, and integrated into the overall project. Because the announcement explicitly requires a clinical trial, a strong application typically needs a realistic trial plan, appropriate endpoints, sound statistical considerations, and clear protections for human subjects, along with operational details showing the team can actually run the study.

Eligibility is broad and covers many types of organizations. Eligible applicants include state, county, and local governments; special district governments; independent school districts; and public housing authorities/Indian housing authorities. Academic institutions are eligible, including public and state-controlled institutions of higher education and private institutions of higher education. The opportunity is also open to nonprofit organizations, whether they have 501(c)(3) status or not (as long as they are not institutions of higher education), as well as for-profit organizations (including small businesses and other for-profits). In addition, federally recognized Native American tribal governments and other Native American tribal organizations are eligible, along with a range of other entities listed as specifically eligible under the announcement, such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) organizations.

From an administrative standpoint, the funding instrument type is a grant, and the activity category is health, with CFDA number 93.286. The opportunity was created on November 30, 2017, and the original closing date shown in the source data is January 7, 2021. The data provided does not specify an award ceiling or the expected number of awards, which usually means applicants must rely on the broader NIH/NIBIB guidance for typical R01 budgeting and review the full announcement details and current NIH policy for any applicable limits, budget formats, and submission requirements.

Overall, this funding opportunity supports investigators who want to pursue a focused biomedical imaging or bioengineering-related research project that includes at least one human clinical trial, with wide eligibility across governmental, academic, nonprofit, for-profit, tribal, and certain international organizations, provided the work fits NIBIB priorities and meets NIH standards for clinical trial design and oversight.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIBIB Research Project Grant (R01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.286.
• This funding opportunity was created on 2017-11-30.
• Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PA 18 418

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