Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01) | PAR 20 230

Opportunity Information: Apply for PAR 20 230

The Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01) opportunity (Funding Opportunity Number PAR-20-230) is an NIH grant mechanism that gives approved research projects access to CIDR's centralized, high-capacity genomic laboratory and statistical genetics support. Rather than primarily providing direct dollars to a grantee to build or expand their own lab capacity, this X01 resource-access model is meant to connect investigators with specialized services that are difficult, inefficient, or too costly to perform in individual laboratories at the same scale and quality. The overall purpose is to speed up gene discovery and the identification of genetic variants or modifications that influence human health and disease, and to strengthen existing studies by adding high-quality genotyping or next-generation sequencing data to well-characterized (well-phenotyped) sample collections.

CIDR's role in this program is to deliver high-throughput genotyping, high-throughput sequencing, and supporting statistical genetics services using current, state-of-the-art platforms. In practical terms, the resource is intended for projects that already have strong scientific questions and well-prepared specimen sets, but need industrial-grade genomic data generation and expert analysis support to move forward. By relying on a shared national resource, projects can maintain consistency, benefit from standardized pipelines and quality control, and take advantage of specialized expertise in study design and statistical genetics that helps ensure the resulting data are interpretable and useful for discovery. The opportunity is described as an NIH-wide initiative managed by the National Human Genome Research Institute (NHGRI), meaning it is available across many disease areas and research domains that NIH supports, not limited to one institute's portfolio.

The services supported through this opportunity are positioned to help in two main ways. First, they can enable studies aimed at identifying genes and variants associated with disease risk, traits, or other health-related outcomes by providing large-scale genotyping or sequencing that supports modern human genetics approaches. Second, they can enhance existing cohorts, case-control collections, family studies, or other well-phenotyped datasets by adding new genotype or sequencing layers, increasing the value of specimens that may have taken years and significant investment to collect and characterize clinically. The emphasis on "well-phenotyped specimens" signals that the program is particularly well-suited to projects where the biological or clinical measurements are already robust, and the missing piece is high-quality genomic data at scale.

Eligibility for applying is broad and reflects NIH's typical inclusivity for research applicants. Eligible applicants include multiple levels of government (state, county, city/township, special district), independent school districts, and public housing authorities/Indian housing authorities. Academic institutions are eligible across public and state-controlled institutions of higher education as well as private institutions of higher education. Tribal entities are included, both federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized governments, along with additional categories explicitly noted such as Indian/Native American Tribal Governments (other than federally recognized), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. The opportunity also allows a wide range of nonprofit organizations (with or without 501(c)(3) status, as long as they are not institutions of higher education in the specific nonprofit category listed) and for-profit organizations (other than small businesses) as well as small businesses. Additional explicitly called-out eligible applicant types include Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Asian American Native American Pacific Islander Serving Institutions (AANAPISI), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-domestic (non-U.S.) entities (foreign organizations), which indicates NIH is open to international participation when consistent with program goals and NIH policy.

Administratively, this opportunity is categorized as a discretionary grant in the health area, under CFDA number 93.172, with the National Institutes of Health as the issuing agency and NHGRI managing the initiative. The posting indicates an original closing date of 2023-06-05 and a creation date of 2020-06-11. The award ceiling and expected number of awards are not specified in the provided data, which is consistent with resource-access programs where the key constraint is often CIDR capacity and programmatic prioritization rather than a set per-award dollar cap listed in the notice. For details on current platforms, services, and likely expectations around sample requirements, data formats, and analysis support, the opportunity directs applicants to CIDR's site at http://www.cidr.jhmi.edu, which is where investigators can typically find updated information on available technologies, project types supported, and operational guidance.

In summary, PAR-20-230 is essentially a pathway for qualified investigators to obtain high-throughput genotyping and sequencing plus statistical genetics support from a national, NHGRI-managed resource, with the goal of accelerating discoveries about how genetic variation influences health and disease and maximizing the research value of existing, well-phenotyped specimen collections.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
• This funding opportunity was created on 2020-06-11.
• Applicants must submit their applications by 2023-06-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 20 230

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: