Opportunity Information: Apply for PAR 20 230
The Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01) opportunity (Funding Opportunity Number PAR-20-230) is an NIH grant mechanism that gives approved research projects access to CIDR's centralized, high-capacity genomic laboratory and statistical genetics support. Rather than primarily providing direct dollars to a grantee to build or expand their own lab capacity, this X01 resource-access model is meant to connect investigators with specialized services that are difficult, inefficient, or too costly to perform in individual laboratories at the same scale and quality. The overall purpose is to speed up gene discovery and the identification of genetic variants or modifications that influence human health and disease, and to strengthen existing studies by adding high-quality genotyping or next-generation sequencing data to well-characterized (well-phenotyped) sample collections.
CIDR's role in this program is to deliver high-throughput genotyping, high-throughput sequencing, and supporting statistical genetics services using current, state-of-the-art platforms. In practical terms, the resource is intended for projects that already have strong scientific questions and well-prepared specimen sets, but need industrial-grade genomic data generation and expert analysis support to move forward. By relying on a shared national resource, projects can maintain consistency, benefit from standardized pipelines and quality control, and take advantage of specialized expertise in study design and statistical genetics that helps ensure the resulting data are interpretable and useful for discovery. The opportunity is described as an NIH-wide initiative managed by the National Human Genome Research Institute (NHGRI), meaning it is available across many disease areas and research domains that NIH supports, not limited to one institute's portfolio.
The services supported through this opportunity are positioned to help in two main ways. First, they can enable studies aimed at identifying genes and variants associated with disease risk, traits, or other health-related outcomes by providing large-scale genotyping or sequencing that supports modern human genetics approaches. Second, they can enhance existing cohorts, case-control collections, family studies, or other well-phenotyped datasets by adding new genotype or sequencing layers, increasing the value of specimens that may have taken years and significant investment to collect and characterize clinically. The emphasis on "well-phenotyped specimens" signals that the program is particularly well-suited to projects where the biological or clinical measurements are already robust, and the missing piece is high-quality genomic data at scale.
Eligibility for applying is broad and reflects NIH's typical inclusivity for research applicants. Eligible applicants include multiple levels of government (state, county, city/township, special district), independent school districts, and public housing authorities/Indian housing authorities. Academic institutions are eligible across public and state-controlled institutions of higher education as well as private institutions of higher education. Tribal entities are included, both federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized governments, along with additional categories explicitly noted such as Indian/Native American Tribal Governments (other than federally recognized), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. The opportunity also allows a wide range of nonprofit organizations (with or without 501(c)(3) status, as long as they are not institutions of higher education in the specific nonprofit category listed) and for-profit organizations (other than small businesses) as well as small businesses. Additional explicitly called-out eligible applicant types include Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Asian American Native American Pacific Islander Serving Institutions (AANAPISI), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-domestic (non-U.S.) entities (foreign organizations), which indicates NIH is open to international participation when consistent with program goals and NIH policy.
Administratively, this opportunity is categorized as a discretionary grant in the health area, under CFDA number 93.172, with the National Institutes of Health as the issuing agency and NHGRI managing the initiative. The posting indicates an original closing date of 2023-06-05 and a creation date of 2020-06-11. The award ceiling and expected number of awards are not specified in the provided data, which is consistent with resource-access programs where the key constraint is often CIDR capacity and programmatic prioritization rather than a set per-award dollar cap listed in the notice. For details on current platforms, services, and likely expectations around sample requirements, data formats, and analysis support, the opportunity directs applicants to CIDR's site at http://www.cidr.jhmi.edu, which is where investigators can typically find updated information on available technologies, project types supported, and operational guidance.
In summary, PAR-20-230 is essentially a pathway for qualified investigators to obtain high-throughput genotyping and sequencing plus statistical genetics support from a national, NHGRI-managed resource, with the goal of accelerating discoveries about how genetic variation influences health and disease and maximizing the research value of existing, well-phenotyped specimen collections.Apply for PAR 20 230
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
- This funding opportunity was created on 2020-06-11.
- Applicants must submit their applications by 2023-06-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: CIDR High Throughput Sequencing and Genotyping Resource Access (X01) (PAR-20-230)
What is the CIDR High Throughput Sequencing and Genotyping Resource Access (X01) opportunity?
This is an NIH resource-access mechanism (X01) that gives approved research projects access to the Center for Inherited Disease Research (CIDR). Instead of primarily awarding funds to build or expand an applicant's own laboratory capacity, it connects investigators to CIDR's centralized, high-capacity genomic laboratory and statistical genetics support.
What is the funding opportunity number for this program?
The Funding Opportunity Number is PAR-20-230.
What does "X01" mean in this context?
In this opportunity, the X01 model is described as a resource-access approach. The main benefit is access to specialized services (high-throughput sequencing, genotyping, and statistical genetics support) delivered by CIDR, rather than a traditional grant focused on providing direct dollars to build local lab infrastructure.
What is the main purpose of this opportunity?
The purpose is to speed up gene discovery and the identification of genetic variants or modifications that influence human health and disease. It is also intended to strengthen existing studies by adding high-quality genotyping or next-generation sequencing data to well-characterized (well-phenotyped) sample collections.
What kinds of services does CIDR provide through this program?
CIDR provides high-throughput genotyping, high-throughput sequencing, and supporting statistical genetics services using current, state-of-the-art platforms, along with expert support that helps with study design and statistical genetics so the resulting data are interpretable and useful for discovery.
Is this program intended to fund my laboratory to generate data in-house?
No. The description emphasizes that this X01 opportunity is not primarily about providing direct funding to a grantee to build or expand their own lab capacity. It is designed to connect investigators to centralized, industrial-scale services that may be difficult, inefficient, or too costly for individual laboratories to perform at the same scale and quality.
What types of research projects are a good fit for this resource?
The opportunity is positioned for projects that already have strong scientific questions and well-prepared specimen sets, but need high-capacity genomic data generation and expert analysis support to move forward.
What does the program mean by "well-phenotyped specimens"?
Based on the description, "well-phenotyped specimens" refers to sample collections tied to robust biological or clinical measurements that are already well characterized. The program is particularly suited when the missing piece is high-quality genomic data at scale.
How can this resource help an existing study or cohort?
It can add new genotype or sequencing layers to existing cohorts, case-control collections, family studies, or other well-phenotyped datasets. This can increase the value of specimens that took significant time and investment to collect and clinically characterize.
What are the two main ways the supported services are intended to help studies?
First, they can enable studies aimed at identifying genes and variants associated with disease risk, traits, or other health-related outcomes by providing large-scale genotyping or sequencing. Second, they can enhance existing well-phenotyped datasets by adding new genomic data layers.
Who manages this initiative at NIH?
The opportunity is described as an NIH-wide initiative managed by the National Human Genome Research Institute (NHGRI).
Is this opportunity limited to a single disease area or NIH institute portfolio?
No. It is described as NIH-wide and available across many disease areas and research domains that NIH supports, not limited to one institute's portfolio.
What is the issuing agency for this opportunity?
The issuing agency is the National Institutes of Health (NIH).
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.172.
How is this opportunity categorized administratively?
It is categorized as a discretionary grant in the health area.
What is the posted closing date and when was the opportunity created?
The posting indicates an original closing date of 2023-06-05 and a creation date of 2020-06-11.
Is there an award ceiling listed for this opportunity?
No. The award ceiling is not specified in the provided information.
Is the expected number of awards specified?
No. The expected number of awards is not specified in the provided information.
Why might award ceilings or award counts be unspecified for this program?
The provided description notes this is consistent with resource-access programs where the key constraint is often CIDR capacity and programmatic prioritization rather than a per-award dollar cap listed in the notice.
What types of applicant organizations are eligible to apply?
Eligibility is broad. The provided information lists multiple levels of government (state, county, city/township, special district), independent school districts, and public housing authorities/Indian housing authorities. It also includes academic institutions (public/state-controlled and private), tribal entities, nonprofits, for-profits, small businesses, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations).
Are tribal entities eligible?
Yes. The listing includes federally recognized Native American tribal governments, Native American tribal organizations that are not federally recognized governments, Indian/Native American Tribal Governments (other than federally recognized), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are minority-serving institutions explicitly included as eligible applicants?
Yes. The eligibility list explicitly calls out Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Asian American Native American Pacific Islander Serving Institutions (AANAPISI), as well as Alaska Native and Native Hawaiian Serving Institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed as eligible applicant types.
Are nonprofit organizations eligible even if they do not have 501(c)(3) status?
Yes. The provided eligibility description includes nonprofit organizations with or without 501(c)(3) status (as long as they fit the noted nonprofit category described in the posting).
Are for-profit organizations eligible, including small businesses?
Yes. The eligibility list includes for-profit organizations (other than small businesses) as well as small businesses.
Can non-U.S. (foreign) organizations apply?
Yes. The eligibility list includes non-domestic (non-U.S.) entities (foreign organizations), indicating openness to international participation when consistent with program goals and NIH policy.
What are the advantages of using a centralized resource like CIDR?
The description highlights that using a shared national resource can help projects maintain consistency, benefit from standardized pipelines and quality control, and access specialized expertise in study design and statistical genetics. This can improve the interpretability and discovery value of the resulting data.
Where can applicants find details on current platforms and operational expectations?
The opportunity directs applicants to CIDR's website for updated details on platforms, services, project types supported, and operational guidance: http://www.cidr.jhmi.edu.
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